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Recent research shows that for people with long-term psychiatric illnesses, such as major depressive disorder, bipolar disorder, or schizophrenia, there are structural changes that take place in the brain.[ref] For me, the mental image is that neurotransmitters are acting like software, and altering the software code can alter mood

The American Journal of Medicine

Circularly permuted dihydrofolate reductase possesses all the properties of the molten globule state, but can resume functional tertiary structure by interaction with its ligands

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plus, the daytime habits to avoid picking/jewelry snagging